Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality ControlIncompletely synthesized proteins (e.g., the products of ribosome stalling during translation) are potentially toxic and must be eliminated. This is a task for Rqc2/NEMF and Ltn1/listerin in the eukaryotic pathway of ribosome-associated protein quality control. Lytvynenko et al. investigate whether prokaryotic Rqc2 homologs function similarly. Their results suggest that organisms in all domains of life have a related, Rqc2-mediated mechanism that extends the C termini of incomplete nascent-chains with peptide sequences (poly-alanine in bacteria) to promote nascent-chain degradation directly or indirectly.Incompletely synthesized proteins (e.g., the products of ribosome stalling during translation) are potentially toxic and must be eliminated. This is a task for Rqc2/NEMF and Ltn1/listerin in the eukaryotic pathway of ribosome-associated protein quality control. Lytvynenko et al. investigate whether prokaryotic Rqc2 homologs function similarly. Their results suggest that organisms in all domains of life have a related, Rqc2-mediated mechanism that extends the C termini of incomplete nascent-chains with peptide sequences (poly-alanine in bacteria) to promote nascent-chain degradation directly or indirectly.Iryna Lytvynenko, Helge Paternoga, Anna Thrun, Annika Balke, Tina A. Müller, Christina H. Chiang, Katja Nagler, George Tsaprailis, Simon Anders, Ilka Bischofs, Julie A. Maupin-Furlow, Christian M.T. Spahn, Claudio A.P. Joazeirohttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2819%2930500-8%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 31, 2019

Powered by WPeMatico