Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolismOgawa et al. report that the intrinsically toxic RNA catabolites m6A, m6,6A, and i6A are detoxified through sequential action of ADK and ADAL, forming IMP. Disruption of this modified adenosine clearance pathway leads to toxic metabolite buildup, AMPK inhibition, and metabolic dysfunction in animal models and human disease.Ogawa et al. report that the intrinsically toxic RNA catabolites m6A, m6,6A, and i6A are detoxified through sequential action of ADK and ADAL, forming IMP. Disruption of this modified adenosine clearance pathway leads to toxic metabolite buildup, AMPK inhibition, and metabolic dysfunction in animal models and human disease.Akiko Ogawa, Satoshi Watanabe, Iuliia Ozerova, Allen Yi-Lun Tsai, Yoshihiko Kuchitsu, Harrison Byron Chong, Tomoyoshi Kawakami, Jirio Fuse, Wei Han, Ryuhei Kudo, Tomoki Naito, Kota Sato, Toru Nakazawa, Yasunori Saheki, Akiyoshi Hirayama, Peter F Stadler, Mieko Arisawa, Kimi Araki, Liron Bar-Peled, Tomohiko Taguchi, Shinichiro Sawa, Kenji Inaba, Fan-Yan Weihttps://www.cell.com/cell/fulltext/S0092-8674(25)00863-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 21, 2025

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