A universal design of betacoronavirus vaccines against COVID-19, MERS and SARSGao et al. present the structure-guided design of a coronavirus immunogen comprised of two protein subunits each containing the of virus spike receptor binding domain fused together via a disulfide link. The immunogen elicits strong immunogenicity in mice and protects them against viral challenge. The vaccine design strategy can be universally applied to SARS, MERS, COVID-19 and other CoV vaccines to counter emerging threats.Gao et al. present the structure-guided design of a coronavirus immunogen comprised of two protein subunits each containing the of virus spike receptor binding domain fused together via a disulfide link. The immunogen elicits strong immunogenicity in mice and protects them against viral challenge. The vaccine design strategy can be universally applied to SARS, MERS, COVID-19 and other CoV vaccines to counter emerging threats.Lianpan Dai, Tianyi Zheng, Kun Xu, Yuxuan Han, Lili Xu, Enqi Huang, Yaling An, Yingjie Cheng, Shihua Li, Mei Liu, Mi Yang, Yan Li, Huijun Cheng, Yuan Yuan, Wei Zhang, Changwen Ke, Gary Wong, Jianxun Qi, Chuan Qin, Jinghua Yan, George F. Gaohttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930812-6%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJune 29, 2020

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