A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infectionThe significant tissue damage imposed by intestinal helminths is controlled by a type 1 immune response. Triggered by the microbiota, gut-resident CD8+ T cells release IFNγ to preserve organ function and host mortality through stromal cell-specific signaling and recruitment of tissue-protective neutrophils.The significant tissue damage imposed by intestinal helminths is controlled by a type 1 immune response. Triggered by the microbiota, gut-resident CD8+ T cells release IFNγ to preserve organ function and host mortality through stromal cell-specific signaling and recruitment of tissue-protective neutrophils.Susan Westfall, Maria E. Gentile, Tayla M. Olsen, Danielle Karo-Atar, Andrei Bogza, Franziska Röstel, Ryan D. Pardy, Giordano Mandato, Ghislaine Fontes, De’Broski Herbert, Heather J. Melichar, Valerie Abadie, Martin J. Richer, Donald C. Vinh, Joshua F.E. Koenig, Oliver J. Harrison, Maziar Divangahi, Sebastian Weis, Alex Gregorieff, Irah L. Kinghttps://www.cell.com/cell/fulltext/S0092-8674(25)00395-2?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 23, 2025
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