A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPREThe microbial-derived bile acid tryptophan-conjugated cholic acid improves type 2 diabetes by promoting GLP-1 secretion in the intestine via activation of the orphan GPCR MRGPRE, revealing another candidate receptor for bile acids and its physiological and pathophysiological importance.The microbial-derived bile acid tryptophan-conjugated cholic acid improves type 2 diabetes by promoting GLP-1 secretion in the intestine via activation of the orphan GPCR MRGPRE, revealing another candidate receptor for bile acids and its physiological and pathophysiological importance.Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu, Linong Ji, Yanli Pang, Jin-Peng Sun, Changtao Jianghttps://www.cell.com/cell/fulltext/S0092-8674(25)00560-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 30, 2025

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