A membrane-associated MHC-I inhibitory axis for cancer immune evasion
A membrane-associated MHC-I inhibitory axis for cancer immune evasionAn inhibitory regulatory axis for membrane-associated MHC-I in acute myeloid leukemia cells is identified; targeting SUSD6/TMEM127/WWP2 axis promotes T cell activity and enhances anti-cancer immunity in leukemia and solid cancers.An inhibitory regulatory axis for membrane-associated MHC-I in acute myeloid leukemia cells is identified; targeting SUSD6/TMEM127/WWP2 axis promotes T cell activity and enhances anti-cancer immunity in leukemia and solid cancers.Xufeng Chen, Qiao Lu, Hua Zhou, Jia Liu, Bettina Nadorp, Audrey Lasry, Zhengxi Sun, Baoling Lai, Gergely Rona, Jiangyan Zhang, Michael Cammer, Kun Wang, Wafa Al-Santli, Zoe Ciantra, Qianjin Guo, Jia You, Debrup Sengupta, Ahmad Boukhris, Hongbing Zhang, Cheng Liu, Peter Cresswell, Patricia L.M. Dahia, Michele Pagano, Iannis Aifantis, Jun Wanghttps://www.cell.com/cell/fulltext/S0092-8674(23)00783-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 9, 2023
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