A mechano-resistance mechanism in skin adapts to terrestrial locomotionAn evolutionarily emerged ER-based mechano-resistance mechanism supports epidermal function under mechanical pressure. SLURP1, an ER membrane protein, preserves SERCA2b activity and calcium homeostasis, preventing pPERK-NRF2 activation to maintain epidermal homeostasis.An evolutionarily emerged ER-based mechano-resistance mechanism supports epidermal function under mechanical pressure. SLURP1, an ER membrane protein, preserves SERCA2b activity and calcium homeostasis, preventing pPERK-NRF2 activation to maintain epidermal homeostasis.Ruonan Di, Qianqian Du, Yuhua Xie, Yanhua Lu, Wenxuan Gao, Lei Zhang, Xiaoli Qi, Yanyan Fan, Jiao Li, Fengchao Wang, She Chen, Ting Chenhttps://www.cell.com/cell/fulltext/S0092-8674(25)00801-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 5, 2025

Powered by WPeMatico