A gut-derived hormone regulates cholesterol metabolismCholesin, a gut-secreted hormone induced by NPC1L1-mediated cholesterol uptake, binds to GPR146, inhibiting PKA-ERK1/2 signaling in the liver. This Cholesin-GPR146 axis suppresses SREBP2-controlled cholesterol synthesis, ultimately reducing circulating cholesterol levels.Cholesin, a gut-secreted hormone induced by NPC1L1-mediated cholesterol uptake, binds to GPR146, inhibiting PKA-ERK1/2 signaling in the liver. This Cholesin-GPR146 axis suppresses SREBP2-controlled cholesterol synthesis, ultimately reducing circulating cholesterol levels.Xiaoli Hu, Fengyi Chen, Liangjie Jia, Aijun Long, Ying Peng, Xu Li, Junfeng Huang, Xueyun Wei, Xinlei Fang, Zihua Gao, Mengxian Zhang, Xiao Liu, Ye-Guang Chen, Yan Wang, Huijie Zhang, Yiguo Wanghttps://www.cell.com/cell/fulltext/S0092-8674(24)00226-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 19, 2024

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