A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cellsA small-molecule-only strategy enables reprogramming ESCs into embryo founder cells that give rise to a high-fidelity embryo model directly and efficiently. This embryo model replicates embryogenesis from initial cell fate specification through E8.5–E8.75-like organogenesis, capturing all key developmental features within a single system.A small-molecule-only strategy enables reprogramming ESCs into embryo founder cells that give rise to a high-fidelity embryo model directly and efficiently. This embryo model replicates embryogenesis from initial cell fate specification through E8.5–E8.75-like organogenesis, capturing all key developmental features within a single system.Huanhuan Li, Wei Guan, Jiahui Huang, Penglei Shen, Jinyi Wu, Haiping Luo, Yun Yang, Shaoqiang Ning, Litao Chang, Haiyong Zhao, Chuanxin Chen, Yake Gao, Yaoyu Chen, Xianfa Yang, Yael Costa, Chen-Leng Cai, Duanqing Pei, Guangdun Peng, Guangming Wu, Jiekai Chen, Jian Zhang, Naihe Jing, José C.R. Silvahttps://www.cell.com/cell/fulltext/S0092-8674(25)00807-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 8, 2025

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