De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsyDe novo protein design was used to engineer a peptide that reverses gain-of-function deficits in voltage-gated sodium channels linked to cardiac arrhythmia and epilepsy.De novo protein design was used to engineer a peptide that reverses gain-of-function deficits in voltage-gated sodium channels linked to cardiac arrhythmia and epilepsy.Ryan Mahling, Bence Hegyi, Erin R. Cullen, Timothy M. Cho, Aaron R. Rodriques, Lucile Fossier, Marc Yehya, Lin Yang, Bi-Xing Chen, Alexander N. Katchman, Nourdine Chakouri, Ruiping Ji, Elaine Y. Wan, Jared Kushner, Steven O. Marx, Sergey Ovchinnikov, Christopher D. Makinson, Donald M. Bers, Manu Ben-Johnyhttps://www.cell.com/cell/fulltext/S0092-8674(25)00860-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 19, 2025

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