Prevalent mesenchymal drift in aging and disease is reversed by partial reprogrammingLoss of cellular identity across aging and disease is linked to a widespread “mesenchymal drift,” characterized by upregulation of mesenchymal genes and altered stromal cell composition across tissues. Mesenchymal drift correlates with worse clinical outcomes, whereas its suppression via Yamanaka factor-induced partial reprogramming restores youthful gene expression.Loss of cellular identity across aging and disease is linked to a widespread “mesenchymal drift,” characterized by upregulation of mesenchymal genes and altered stromal cell composition across tissues. Mesenchymal drift correlates with worse clinical outcomes, whereas its suppression via Yamanaka factor-induced partial reprogramming restores youthful gene expression.Jinlong Y. Lu, William B. Tu, Ronghui Li, Mingxi Weng, Bhargav D. Sanketi, Baolei Yuan, Pradeep Reddy, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmontehttps://www.cell.com/cell/fulltext/S0092-8674(25)00853-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 15, 2025

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