VIVIT: Resolving trans-scale volumetric biological architectures via ionic glassy tissueLeveraging the chemical properties of ionic liquids, VIVIT transforms biological tissue into a glassy state, addressing long-standing challenges in the optical clearing field. This enables precise and reliable mapping of trans-scale biostructures, facilitating the discovery of a link between the synaptic inputs and brain-wide outputs of higher-order auditory thalamic neurons and a distinct positioning pattern of parvalbumin+ synaptic terminals on human cortical pyramidal neurons.Leveraging the chemical properties of ionic liquids, VIVIT transforms biological tissue into a glassy state, addressing long-standing challenges in the optical clearing field. This enables precise and reliable mapping of trans-scale biostructures, facilitating the discovery of a link between the synaptic inputs and brain-wide outputs of higher-order auditory thalamic neurons and a distinct positioning pattern of parvalbumin+ synaptic terminals on human cortical pyramidal neurons.Yixiao Gao, Fengyuan Xin, Tao Wang, Chengjun Shao, Ying Hu, Zhuoya Chen, Yiwei Wang, Fenghua Xie, Tianyu Li, Sijie Li, Liqun Ren, Caiqin Li, Xian Yang, Zhongjun Yang, Meijie Li, KaMun Tan, Tao Bai, Changwei Wei, Hanchuan Peng, Kun Li, Yichang Jia, Kexin Yuanhttps://www.cell.com/cell/fulltext/S0092-8674(25)00813-X?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 12, 2025

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