Highly conserved Betacoronavirus sequences are broadly recognized by human T cellsCombining spike and conserved regions of non-spike proteins from Betacoronaviruses in vaccination approaches induces broad T cell responses that show cross-reactivity between multiple related viruses. Focusing on these conserved T cell epitope regions represents a strategy for optimizing vaccination against viral families of pandemic concern.Combining spike and conserved regions of non-spike proteins from Betacoronaviruses in vaccination approaches induces broad T cell responses that show cross-reactivity between multiple related viruses. Focusing on these conserved T cell epitope regions represents a strategy for optimizing vaccination against viral families of pandemic concern.Tertuliano Alves Pereira Neto, Christian Zmasek, Liliana Avalos, John Sidney, Raphael Trevizani, Elizabeth Phillips, Simon Mallal, April Frazier, Gene S. Tan, Richard H. Scheuermann, Alessandro Sette, Alba Grifonihttps://www.cell.com/cell/fulltext/S0092-8674(25)00804-9?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 7, 2025

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