Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scalesHigh-throughput recombination site screening with AI-assisted recombinase engineering allows for the development of an iterative Cre-Lox system that, when combined with a scar-free prime editing strategy, enables programmable and seamless chromosome editing from kilobase to megabase scale across diverse genomes.High-throughput recombination site screening with AI-assisted recombinase engineering allows for the development of an iterative Cre-Lox system that, when combined with a scar-free prime editing strategy, enables programmable and seamless chromosome editing from kilobase to megabase scale across diverse genomes.Chao Sun, Hongchao Li, Yijing Liu, Yunjia Li, Rui Gao, Xiaoli Shi, Hongyuan Fei, Jinxing Liu, Ronghong Liang, Caixia Gaohttps://www.cell.com/cell/fulltext/S0092-8674(25)00800-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 5, 2025

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