The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatmentAn arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway affecting parasite growth and sexual development exposed a vulnerability that can be leveraged for treatment.An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway affecting parasite growth and sexual development exposed a vulnerability that can be leveraged for treatment.N. Bishara Marzook, Ok-Ryul Song, Lotta Baumgärtel, Netanya Bernitz, Tapoka T. Mkandawire, Lucy C. Watson, Vanessa Nunes, Scott Warchal, James I. MacRae, Michael Howell, Adam Saterialehttps://www.cell.com/cell/fulltext/S0092-8674(25)00751-2?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 24, 2025

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