Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effectsFecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism and immune function. This research suggests that personalized, intestinal-region-specific microbiome therapies are needed to improve outcomes and avoid mismatches that could impact gut health and disease.Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism and immune function. This research suggests that personalized, intestinal-region-specific microbiome therapies are needed to improve outcomes and avoid mismatches that could impact gut health and disease.Orlando DeLeon, Mora Mocanu, Alan Tan, Ashley M. Sidebottom, Jason Koval, Hugo D. Ceccato, Sarah Kralicek, John J. Colgan, Marissa M. St. George, Joash M. Lake, Michael Cooper, Jingwen Xu, Julia Moore, Qi Su, Zhilu Xu, Siew C. Ng, Francis K.L. Chan, Hein M. Tun, Candace M. Cham, Cambrian Y. Liu, David T. Rubin, Kristina Martinez-Guryn, Eugene B. Changhttps://www.cell.com/cell/fulltext/S0092-8674(25)00564-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJune 7, 2025

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