Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregatesStress granules promote TDP-43 aggregation via intra-condensate demixing, a pathway triggered by its up-concentration and oxidation within condensates. Blocking this demixing pathway prevents TDP-43 aggregation, highlighting a potential therapeutic strategy for ALS/FTD diseases.Stress granules promote TDP-43 aggregation via intra-condensate demixing, a pathway triggered by its up-concentration and oxidation within condensates. Blocking this demixing pathway prevents TDP-43 aggregation, highlighting a potential therapeutic strategy for ALS/FTD diseases.Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Jorge Garcia Morato, Azamat Rizuan, Titus M. Franzmann, Aleksandra Sergeeva, Anh M. Ly, Feilin Liu, Patricia M. Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L. Danielson, Busra Ozguney, Alf Honigmann, Yuna M. Ayala, Nicolas L. Fawzi, Dennis W. Dickson, Wilfried Rossoll, Jeetain Mittal, Simon Alberti, Anthony A. Hymanhttps://www.cell.com/cell/fulltext/S0092-8674(25)00509-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 24, 2025

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