Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neuronsIn mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these impairments, as lowering levels rectifies deficits and AD patient-derived extracts selectively compromise burst generation.In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these impairments, as lowering levels rectifies deficits and AD patient-derived extracts selectively compromise burst generation.Samuel S. Harris, Robert Ellingford, Jana Hartmann, Debanjan Dasgupta, Marten Kehring, Rikesh M. Rajani, David Graykowski, Noé Quittot, Dhanush Sivasankaran, Caitlin Commins, Zhanyun Fan, Suraya A. Bond, Fred Wolf, David Dupret, Raymond J. Dolan, Arthur Konnerth, Andreas Neef, Bradley T. Hyman, Marc Aurel Buschehttps://www.cell.com/cell/fulltext/S0092-8674(25)00408-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 29, 2025

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