Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasisActivation of PNOCARC neurons promotes feeding. Here, Solheim et al. describe PNOC neurons in the murine ARC as mediators of leptin action in body weight maintenance. Moreover, they molecularly and functionally define a specific PNOCARC subtype, characterized by co-expression of PNOC and NPY, which is conserved in humans and regulates feeding in mice.Activation of PNOCARC neurons promotes feeding. Here, Solheim et al. describe PNOC neurons in the murine ARC as mediators of leptin action in body weight maintenance. Moreover, they molecularly and functionally define a specific PNOCARC subtype, characterized by co-expression of PNOC and NPY, which is conserved in humans and regulates feeding in mice.Marie H. Solheim, Sima Stroganov, Weiyi Chen, P. Sicilia Subagia, Corinna A. Bauder, Daria Wnuk-Lipinski, Almudena Del Río-Martín, Tamara Sotelo-Hitschfeld, Cait A. Beddows, Paul Klemm, Garron T. Dodd, Sofia Lundh, Anna Secher, F. Thomas Wunderlich, Lukas Steuernagel, Jens C. Brüninghttps://www.cell.com/cell/fulltext/S0092-8674(25)00403-9?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 24, 2025

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