Integrator loss leads to dsRNA formation that triggers the integrated stress responseIntegrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.Apoorva Baluapuri, Nicole ChenCheng Zhao, Ryan J. Marina, Kai-Lieh Huang, Anastasia Kuzkina, Maria E. Amodeo, Chad B. Stein, Lucie Y. Ahn, Jordan S. Farr, Ashleigh E. Schaffer, Vikram Khurana, Eric J. Wagner, Karen Adelmanhttps://www.cell.com/cell/fulltext/S0092-8674(25)00343-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 15, 2025

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