Bacterial immunotherapy leveraging IL-10R hysteresis for both phagocytosis evasion and tumor immunity revitalizationIL-10R expression on tumor-infiltrating immune cells exhibits a hysteretic response to intratumor IL-10 concentration. Leveraging such a property, an engineered Salmonella enterica strain can reconcile the long-standing dual challenge in bacterial cancer therapy: evading antimicrobial immune defenses while promoting anti-tumor activity.IL-10R expression on tumor-infiltrating immune cells exhibits a hysteretic response to intratumor IL-10 concentration. Leveraging such a property, an engineered Salmonella enterica strain can reconcile the long-standing dual challenge in bacterial cancer therapy: evading antimicrobial immune defenses while promoting anti-tumor activity.Zhiguang Chang, Xuan Guo, Xuefei Li, Yan Wang, Zhongsheng Zang, Siyu Pei, Weiqi Lu, Yang Li, Jian-Dong Huang, Yichuan Xiao, Chenli Liuhttps://www.cell.com/cell/fulltext/S0092-8674(25)00158-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 4, 2025

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