Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD miceGenes encoding distinct mismatch-repair complexes (i.e., Msh3 and Pms1) set a fast CAG-repeat expansion rate in vulnerable neurons to drive selective and progressive striatal and cortical pathogenesis in a mouse model of Huntington’s disease (HD).Genes encoding distinct mismatch-repair complexes (i.e., Msh3 and Pms1) set a fast CAG-repeat expansion rate in vulnerable neurons to drive selective and progressive striatal and cortical pathogenesis in a mouse model of Huntington’s disease (HD).Nan Wang, Shasha Zhang, Peter Langfelder, Lalini Ramanathan, Fuying Gao, Mary Plascencia, Raymond Vaca, Xiaofeng Gu, Linna Deng, Leonardo E. Dionisio, Ha Vu, Emily Maciejewski, Jason Ernst, Brinda C. Prasad, Thomas F. Vogt, Steve Horvath, Jeffrey S. Aaronson, Jim Rosinski, X. William Yanghttps://www.cell.com/cell/fulltext/S0092-8674(25)00100-X?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignFebruary 12, 2025

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