Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral targetAn early fusion intermediate conformation of the SARS-CoV-2 spike protein induced by ACE2 binding is uncovered. AL5E is an engineered protein that targets this structure, exhibits potent inactivation of ACE2-using coronaviruses, and inhibits their infection, thus revealing a new class of anti-coronavirus targets.An early fusion intermediate conformation of the SARS-CoV-2 spike protein induced by ACE2 binding is uncovered. AL5E is an engineered protein that targets this structure, exhibits potent inactivation of ACE2-using coronaviruses, and inhibits their infection, thus revealing a new class of anti-coronavirus targets.Lixiao Xing, Zhimin Liu, Xinling Wang, Qianying Liu, Wei Xu, Qiyu Mao, Xiang Zhang, Aihua Hao, Shuai Xia, Zezhong Liu, Lujia Sun, Guangxu Zhang, Qian Wang, Zhenguo Chen, Shibo Jiang, Lei Sun, Lu Luhttps://www.cell.com/cell/fulltext/S0092-8674(25)00041-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 31, 2025

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