Identification, structure, and agonist design of an androgen membrane receptorGPR133 is identified as a membrane receptor for the androgen subtype 5α-DHT, and the cryo-EM structures define the determinants for androgen recognition, enabling the generation of a GPR133 agonist that allows for selective modulation of muscle strength in mice.GPR133 is identified as a membrane receptor for the androgen subtype 5α-DHT, and the cryo-EM structures define the determinants for androgen recognition, enabling the generation of a GPR133 agonist that allows for selective modulation of muscle strength in mice.Zhao Yang, Yu-Qi Ping, Ming-Wei Wang, Chao Zhang, Shu-Hua Zhou, Yue-Tong Xi, Kong-Kai Zhu, Wei Ding, Qi-Yue Zhang, Zhi-Chen Song, Ru-Jia Zhao, Zi-Lu He, Meng-Xin Wang, Lei Qi, Christian Ullmann, Albert Ricken, Torsten Schöneberg, Zhen-Ji Gan, Xiao Yu, Peng Xiao, Fan Yi, Ines Liebscher, Jin-Peng Sunhttps://www.cell.com/cell/fulltext/S0092-8674(25)00035-2?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 30, 2025

Powered by WPeMatico