Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4Structures of GPR4 from Mus musculus and Xenopus under various pH conditions are solved to elucidate the common and distinct activation mechanisms of protonation-induced GPR4 from different species. Evolutionary analysis and functional study identify that the GPR4 receptor from Xenopus has a distinct optimal pH activation profile associated with its adaptation to aquatic life.Structures of GPR4 from Mus musculus and Xenopus under various pH conditions are solved to elucidate the common and distinct activation mechanisms of protonation-induced GPR4 from different species. Evolutionary analysis and functional study identify that the GPR4 receptor from Xenopus has a distinct optimal pH activation profile associated with its adaptation to aquatic life.Xin Wen, Pan Shang, Haidi Chen, Lulu Guo, Naikang Rong, Xiaoyu Jiang, Xuan Li, Junyan Liu, Gongming Yang, Jiacheng Zhang, Kongkai Zhu, Qingbiao Meng, Xuefei He, Zhihai Wang, Zili Liu, Haoran Cheng, Yilin Zheng, Bifei Zhang, Jiaojiao Pang, Zhaoqian Liu, Peng Xiao, Yuguo Chen, Lunxu Liu, Fengming Luo, Xiao Yu, Fan Yi, Pengju Zhang, Fan Yang, Cheng Deng, Jin-Peng Sunhttps://www.cell.com/cell/fulltext/S0092-8674(24)01380-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 3, 2025

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