DNA end sensing and cleavage by the Shedu anti-phage defense systemShedu is a single-component prokaryotic defense system that provides immunity against bacteriophages, using the tetrameric protein SduA that recognizes and nicks free DNA ends. The DNA end-sensing mechanism of Shedu reinforces the principle of molecular pattern recognition that underpins innate immunity in all domains of life.Shedu is a single-component prokaryotic defense system that provides immunity against bacteriophages, using the tetrameric protein SduA that recognizes and nicks free DNA ends. The DNA end-sensing mechanism of Shedu reinforces the principle of molecular pattern recognition that underpins innate immunity in all domains of life.Luuk Loeff, Alexander Walter, Gian Tizio Rosalen, Martin Jinekhttps://www.cell.com/cell/fulltext/S0092-8674(24)01346-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 1, 2025

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