Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendritesIn neuronal dendrites of both rodents and flies, there are regularly spaced contact sites between the endoplasmic reticulum (ER) and plasma membrane, which function as hubs for regulating Ca2+ homeostasis and facilitate long-range transmission of signals along the length of the dendrite. The ladder-like patterning of the neuronal ER and its plasma membrane junctions resembles that of the sarcoplasmic reticulum-plasma membrane junctions in muscles.In neuronal dendrites of both rodents and flies, there are regularly spaced contact sites between the endoplasmic reticulum (ER) and plasma membrane, which function as hubs for regulating Ca2+ homeostasis and facilitate long-range transmission of signals along the length of the dendrite. The ladder-like patterning of the neuronal ER and its plasma membrane junctions resembles that of the sarcoplasmic reticulum-plasma membrane junctions in muscles.Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, Pietro De Camilli, Timothy A. Ryan, Jennifer Lippincott-Schwartzhttps://www.cell.com/cell/fulltext/S0092-8674(24)01345-X?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 21, 2024

Powered by WPeMatico