Decoding transcriptional identity in developing human sensory neurons and organoid modelingA spatiotemporal developmental atlas of human dorsal root ganglia (DRGs) reveals the diversity of cell types as well as the signaling pathways and transcription factors (TFs) that regulate sensory neuron differentiation and specification. Human DRG organoids, generated with an advanced culture method incorporating these essential signals, recapitulate human DRG development in vitro.A spatiotemporal developmental atlas of human dorsal root ganglia (DRGs) reveals the diversity of cell types as well as the signaling pathways and transcription factors (TFs) that regulate sensory neuron differentiation and specification. Human DRG organoids, generated with an advanced culture method incorporating these essential signals, recapitulate human DRG development in vitro.Tian Lu, Mengdi Wang, Wei Zhou, Qi Ni, Yuanlei Yue, Wei Wang, Yingchao Shi, Zeyuan Liu, Changlin Li, Bei Hong, Xin Zhou, Suijuan Zhong, Kaikai Wang, Bo Zeng, Jun Zhang, Wei Wang, Xu Zhang, Qian Wu, Xiaoqun Wanghttps://www.cell.com/cell/fulltext/S0092-8674(24)01205-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 13, 2024

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