Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocketMorstein et al. demonstrate the feasibility of inhibiting GTPases beyond K-Ras, including various Ras-, Rho-, and Rab-family GTPases that were previously considered undruggable.Morstein et al. demonstrate the feasibility of inhibiting GTPases beyond K-Ras, including various Ras-, Rho-, and Rab-family GTPases that were previously considered undruggable.Johannes Morstein, Victoria Bowcut, Micah Fernando, Yue Yang, Lawrence Zhu, Meredith L. Jenkins, John T. Evans, Keelan Z. Guiley, D. Matthew Peacock, Sophie Krahnke, Zhi Lin, Katrine A. Taran, Benjamin J. Huang, Andrew G. Stephen, John E. Burke, Felice C. Lightstone, Kevan M. Shokathttps://www.cell.com/cell/fulltext/S0092-8674(24)00908-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 10, 2024

Powered by WPeMatico