Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatmentVaginal microbiota dominance by Lactobacillus iners is associated with recurrence of bacterial vaginosis (BV), a widely prevalent syndrome, whereas microbiota dominance by other Lactobacillus species is more protective. Unsaturated long-chain fatty acids like oleic acid can simultaneously inhibit L. iners and BV-associated bacteria while promoting growth of non-iners lactobacilli, promoting a more health-associated microbiome composition in an in vitro model.Vaginal microbiota dominance by Lactobacillus iners is associated with recurrence of bacterial vaginosis (BV), a widely prevalent syndrome, whereas microbiota dominance by other Lactobacillus species is more protective. Unsaturated long-chain fatty acids like oleic acid can simultaneously inhibit L. iners and BV-associated bacteria while promoting growth of non-iners lactobacilli, promoting a more health-associated microbiome composition in an in vitro model.Meilin Zhu, Matthew W. Frank, Christopher D. Radka, Sarah Jeanfavre, Jiawu Xu, Megan W. Tse, Julian Avila Pacheco, Jae Sun Kim, Kerry Pierce, Amy Deik, Fatima Aysha Hussain, Joseph Elsherbini, Salina Hussain, Nondumiso Xulu, Nasreen Khan, Vanessa Pillay, Caroline M. Mitchell, Krista L. Dong, Thumbi Ndung’u, Clary B. Clish, Charles O. Rock, Paul C. Blainey, Seth M. Bloom, Douglas S. Kwonhttps://www.cell.com/cell/fulltext/S0092-8674(24)00823-7?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 20, 2024

Powered by WPeMatico