Mining human microbiomes reveals an untapped source of peptide antibioticsComputational analysis of 1,773 human gut metagenomes led to the discovery of 323 candidate antibiotics encoded in small open reading frames, known as smORF-encoded peptides (SEPs). These SEPs exhibit potent antibiotic properties against clinically relevant pathogens, both in vitro and in vivo.Computational analysis of 1,773 human gut metagenomes led to the discovery of 323 candidate antibiotics encoded in small open reading frames, known as smORF-encoded peptides (SEPs). These SEPs exhibit potent antibiotic properties against clinically relevant pathogens, both in vitro and in vivo.Marcelo D.T. Torres, Erin F. Brooks, Angela Cesaro, Hila Sberro, Matthew O. Gill, Cosmos Nicolaou, Ami S. Bhatt, Cesar de la Fuente-Nunezhttps://www.cell.com/cell/fulltext/S0092-8674(24)00802-X?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 20, 2024

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