Contrasting somatic mutation patterns in aging human neurons and oligodendrocytesBy employing single-cell whole-genome sequencing and integrating single-nucleus RNA-seq and single-nucleus ATAC-seq from the same individuals, this study uncovers distinct aging-related patterns of somatic mutation in human oligodendrocytes and neurons, which contribute to a deeper understanding of the mechanisms involved in human brain aging.By employing single-cell whole-genome sequencing and integrating single-nucleus RNA-seq and single-nucleus ATAC-seq from the same individuals, this study uncovers distinct aging-related patterns of somatic mutation in human oligodendrocytes and neurons, which contribute to a deeper understanding of the mechanisms involved in human brain aging.Javier Ganz, Lovelace J. Luquette, Sara Bizzotto, Michael B. Miller, Zinan Zhou, Craig L. Bohrson, Hu Jin, Antuan V. Tran, Vinayak V. Viswanadham, Gannon McDonough, Katherine Brown, Yasmine Chahine, Brian Chhouk, Alon Galor, Peter J. Park, Christopher A. Walshhttps://www.cell.com/cell/fulltext/S0092-8674(24)00227-7?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 19, 2024

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