Structural and signaling mechanisms of TAAR1 enabled preferential agonist designStructural basis for the molecular recognition and signaling diversity of TAAR1 has been revealed, which facilitates structure-based preferential Gq or dual Gs/Gq pathway agonist design to alleviate MK-801-induced schizophrenia-like phenotypes.Structural basis for the molecular recognition and signaling diversity of TAAR1 has been revealed, which facilitates structure-based preferential Gq or dual Gs/Gq pathway agonist design to alleviate MK-801-induced schizophrenia-like phenotypes.Pan Shang, Naikang Rong, Jing-Jing Jiang, Jie Cheng, Ming-Hui Zhang, Dongwei Kang, Lei Qi, Lulu Guo, Gong-Ming Yang, Qun Liu, Zhenzhen Zhou, Xiao-Bing Li, Kong-Kai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Dapeng Lei, Xin Feng, Xinyong Liu, Xiao Yu, Yue Wang, Qian Li, Zhen-Hua Shao, Fan Yang, Jin-Peng Sunhttps://www.cell.com/cell/fulltext/S0092-8674(23)01131-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 14, 2023

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