Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement

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Epigenetic balance ensures mechanistic control of MLL amplification and rearrangementAn imbalance in histone modifications contributes to both transient amplifications and integrated rearrangements and amplifications observed in leukemia, which can be induced by a commonly used chemotherapy but prevented by chemical intervention.An imbalance in histone modifications contributes to both transient amplifications and integrated rearrangements and amplifications observed in leukemia, which can be induced by a commonly used chemotherapy but prevented by chemical intervention.Zach H. Gray, Damayanti Chakraborty, Reuben R. Duttweiler, Gulnaz D. Alekbaeva, Sedona E. Murphy, Kashish Chetal, Fei Ji, Benjamin I. Ferman, Madison A. Honer, Zhentian Wang, Cynthia Myers, Renhong Sun, H. Ümit Kaniskan, Monika Maria Toma, Elena A. Bondarenko, John N. Santoro, Christopher Miranda, Megan E. Dillingham, Ran Tang, Or Gozani, Jian Jin, Tomasz Skorski, Cihangir Duy, Hayan Lee, Ruslan I. Sadreyev, Johnathan R. Whetstinehttps://www.cell.com/cell/fulltext/S0092-8674(23)01028-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 3, 2023

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