Structural basis for ion selectivity in potassium-selective channelrhodopsinsK+-selective channelrhodopsins (HcKCR1/2) are discovered to work via an asymmetric selectivity gate and a distinct dehydration pathway within the channel; based on the structures obtained here, KCR variants with increased K+ selectivity are generated.K+-selective channelrhodopsins (HcKCR1/2) are discovered to work via an asymmetric selectivity gate and a distinct dehydration pathway within the channel; based on the structures obtained here, KCR variants with increased K+ selectivity are generated.Seiya Tajima, Yoon Seok Kim, Masahiro Fukuda, YoungJu Jo, Peter Y. Wang, Joseph M. Paggi, Masatoshi Inoue, Eamon F.X. Byrne, Koichiro E. Kishi, Seiwa Nakamura, Charu Ramakrishnan, Shunki Takaramoto, Takashi Nagata, Masae Konno, Masahiro Sugiura, Kota Katayama, Toshiki E. Matsui, Keitaro Yamashita, Suhyang Kim, Hisako Ikeda, Jaeah Kim, Hideki Kandori, Ron O. Dror, Keiichi Inoue, Karl Deisseroth, Hideaki E. Katohttps://www.cell.com/cell/fulltext/S0092-8674(23)00863-2?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 31, 2023

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