Cyclin E-induced replicative stress drives p53-dependent whole-genome duplicationDNA replication stress-induced whole-genome duplication (WGD) requires p53 function, in contrast to WGD induced by DNA damage; these findings provide mechanistic insight into cancer genome evolution in p53+/+ tumors.DNA replication stress-induced whole-genome duplication (WGD) requires p53 function, in contrast to WGD induced by DNA damage; these findings provide mechanistic insight into cancer genome evolution in p53+/+ tumors.Jingkun Zeng, Stephanie A. Hills, Eiko Ozono, John F.X. Diffleyhttps://www.cell.com/cell/fulltext/S0092-8674(22)01579-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 21, 2023

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