A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralizationSingh et al. demonstrate that plasma IgM contributes to early Zika virus neutralization during pregnancy and isolate a pentameric IgM from a Zika virus-infected pregnant woman whose child was born without evidence of congenital Zika syndrome. This IgM’s ultrapotent neutralization in vitro and efficient protection from virus challenge in mice depends on its isotype, which enables modes of antigen recognition not available to IgG.Singh et al. demonstrate that plasma IgM contributes to early Zika virus neutralization during pregnancy and isolate a pentameric IgM from a Zika virus-infected pregnant woman whose child was born without evidence of congenital Zika syndrome. This IgM’s ultrapotent neutralization in vitro and efficient protection from virus challenge in mice depends on its isotype, which enables modes of antigen recognition not available to IgG.Tulika Singh, Kwan-Ki Hwang, Andrew S. Miller, Rebecca L. Jones, Cesar A. Lopez, Sarah J. Dulson, Camila Giuberti, Morgan A. Gladden, Itzayana Miller, Helen S. Webster, Joshua A. Eudailey, Kan Luo, Tarra Von Holle, Robert J. Edwards, Sarah Valencia, Katherine E. Burgomaster, Summer Zhang, Jesse F. Mangold, Joshua J. Tu, Maria Dennis, S. Munir Alam, Lakshmanane Premkumar, Reynaldo Dietze, Theodore C. Pierson, Eng Eong Ooi, Helen M. Lazear, Richard J. Kuhn, Sallie R. Permar, Mattia Bonsignorihttps://www.cell.com/cell/fulltext/S0092-8674(22)01369-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 19, 2022

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