Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants including BA.4 and BA.5The SARS-CoV-2 Omicron variants BA.4 and BA.5 are currently causing infections and COVID-19 morbidities worldwide. Compared to the earlier variant BA.2, BA.4/5 show more efficient replication and are more fusogenic. Structural views as well as in vivo studies in hamsters explain the antibody evasion and increased pathogenicity of BA.4/5 is over BA.2.The SARS-CoV-2 Omicron variants BA.4 and BA.5 are currently causing infections and COVID-19 morbidities worldwide. Compared to the earlier variant BA.2, BA.4/5 show more efficient replication and are more fusogenic. Structural views as well as in vivo studies in hamsters explain the antibody evasion and increased pathogenicity of BA.4/5 is over BA.2.Izumi Kimura, Daichi Yamasoba, Tomokazu Tamura, Naganori Nao, Tateki Suzuki, Yoshitaka Oda, Shuya Mitoma, Jumpei Ito, Hesham Nasser, Jiri Zahradnik, Keiya Uriu, Shigeru Fujita, Yusuke Kosugi, Lei Wang, Masumi Tsuda, Mai Kishimoto, Hayato Ito, Rigel Suzuki, Ryo Shimizu, M.S.T. Monira Begum, Kumiko Yoshimatsu, Kanako Terakado Kimura, Jiei Sasaki, Kaori Sasaki-Tabata, Yuki Yamamoto, Tetsuharu Nagamoto, Jun Kanamune, Kouji Kobiyama, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Kotaro Shirakawa, Akifumi Takaori-Kondo, Jin Kuramochi, Gideon Schreiber, Ken J. Ishii, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Takao Hashiguchi, Terumasa Ikeda, Akatsuki Saito, Takasuke Fukuhara, Shinya Tanaka, Keita Matsuno, Kei Satohttps://www.cell.com/cell/fulltext/S0092-8674(22)01190-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 14, 2022

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