The intrinsic and extrinsic effects of TET proteins during gastrulationSingle-embryo, single-cell temporal models of embryos lacking Tet contribution, either partially or fully, clarify the cell-intrinsic effects of the TET machinery from its subsequent tissue-level ramifications. TET-mediated demethylation alters gene expression in a lineage- and time-specific fashion, but such alterations can be overcome in the presence of inter-cellular signals from neighboring cells.Single-embryo, single-cell temporal models of embryos lacking Tet contribution, either partially or fully, clarify the cell-intrinsic effects of the TET machinery from its subsequent tissue-level ramifications. TET-mediated demethylation alters gene expression in a lineage- and time-specific fashion, but such alterations can be overcome in the presence of inter-cellular signals from neighboring cells.Saifeng Cheng, Markus Mittnenzweig, Yoav Mayshar, Aviezer Lifshitz, Marko Dunjić, Yoach Rais, Raz Ben-Yair, Stephanie Gehrs, Elad Chomsky, Zohar Mukamel, Hernan Rubinstein, Katharina Schlereth, Netta Reines, Ayelet-Hashahar Orenbuch, Amos Tanay, Yonatan Stelzerhttps://www.cell.com/cell/fulltext/S0092-8674(22)00842-X?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 31, 2022

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