Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cellsMedullary thymic epithelial cells repurpose the lineage-defining transcription factors of diverse extra-thymic cell types to create cellular mimics of the peripheral self within the thymus, allowing for self-tolerization of maturing T cells.Medullary thymic epithelial cells repurpose the lineage-defining transcription factors of diverse extra-thymic cell types to create cellular mimics of the peripheral self within the thymus, allowing for self-tolerization of maturing T cells.Daniel A. Michelson, Koji Hase, Tsuneyasu Kaisho, Christophe Benoist, Diane Mathishttps://www.cell.com/cell/fulltext/S0092-8674(22)00649-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJune 17, 2022

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