BacPROTACs mediate targeted protein degradation in bacteria

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BacPROTACs mediate targeted protein degradation in bacteriaSmall-molecule adaptors, BacPROTACs, redirect bacterial ClpCP protease to target neo-substrates in a highly specific manner and expand targeted protein degradation technology to bacteria.Small-molecule adaptors, BacPROTACs, redirect bacterial ClpCP protease to target neo-substrates in a highly specific manner and expand targeted protein degradation technology to bacteria.Francesca E. Morreale, Stefan Kleine, Julia Leodolter, Sabryna Junker, David M. Hoi, Stepan Ovchinnikov, Anastasia Okun, Juliane Kley, Robert Kurzbauer, Lukas Junk, Somraj Guha, David Podlesainski, Uli Kazmaier, Guido Boehmelt, Harald Weinstabl, Klaus Rumpel, Volker M. Schmiedel, Markus Hartl, David Haselbach, Anton Meinhart, Markus Kaiser, Tim Clausenhttps://www.cell.com/cell/fulltext/S0092-8674(22)00593-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJune 10, 2022

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