Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agentsInterference with viral negative feedback loops results in overexpression of cytotoxic viral proteins and host cell death, presenting an approach to antiviral therapy with a high barrier to the evolution of resistance.Interference with viral negative feedback loops results in overexpression of cytotoxic viral proteins and host cell death, presenting an approach to antiviral therapy with a high barrier to the evolution of resistance.Sonali Chaturvedi, Michael Pablo, Marie Wolf, Daniel Rosas-Rivera, Giuliana Calia, Arjun J. Kumar, Noam Vardi, Kelvin Du, Joshua Glazier, Ruian Ke, Matilda F. Chan, Alan S. Perelson, Leor S. Weinbergerhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2822%2900469-X%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 13, 2022

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