Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive nicheSpatially resolved transcriptome analysis of tumors identifies quiescent cell niches that instruct T cells to be hyporesponsive, thus suggesting a route for therapeutic targeting in triple-negative breast cancer.Spatially resolved transcriptome analysis of tumors identifies quiescent cell niches that instruct T cells to be hyporesponsive, thus suggesting a route for therapeutic targeting in triple-negative breast cancer.Pilar Baldominos, Alex Barbera-Mourelle, Olga Barreiro, Yu Huang, Andrew Wight, Jae-Won Cho, Xi Zhao, Guillem Estivill, Isam Adam, Xavier Sanchez, Shannon McCarthy, Julien Schaller, Zara Khan, Albert Ruzo, Ricardo Pastorello, Edward T. Richardson, Deborah Dillon, Paula Montero-Llopis, Romualdo Barroso-Sousa, Juliet Forman, Sachet A. Shukla, Sara M. Tolaney, Elizabeth A. Mittendorf, Ulrich H. von Andrian, Kai W. Wucherpfennig, Martin Hemberg, Judith Agudohttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2822%2900343-9%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 21, 2022

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