Metabolic modeling of single Th17 cells reveals regulators of autoimmunityCompass is an algorithm that derives information on cellular metabolic states from single-cell transcriptomic data. When applied to Th17 cells, it provides insights into how targeting the polyamine pathway can modulate encephalitis-associated T cells and attenuate autoimmune disease associated with the CNS.Compass is an algorithm that derives information on cellular metabolic states from single-cell transcriptomic data. When applied to Th17 cells, it provides insights into how targeting the polyamine pathway can modulate encephalitis-associated T cells and attenuate autoimmune disease associated with the CNS.Allon Wagner, Chao Wang, Johannes Fessler, David DeTomaso, Julian Avila-Pacheco, James Kaminski, Sarah Zaghouani, Elena Christian, Pratiksha Thakore, Brandon Schellhaass, Elliot Akama-Garren, Kerry Pierce, Vasundhara Singh, Noga Ron-Harel, Vivian Paraskevi Douglas, Lloyd Bod, Alexandra Schnell, Daniel Puleston, Raymond A. Sobel, Marcia Haigis, Erika L. Pearce, Manoocher Soleimani, Clary Clish, Aviv Regev, Vijay K. Kuchroo, Nir Yosefhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2900700-5%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 3, 2021

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