Structure and gating mechanism of the α7 nicotinic acetylcholine receptorCryo-EM structures of the α7 nicotinic acetylcholine receptor in three major conformational states of the gating cycle—resting, activated, and desensitized—along with functional studies reveal components involved in calcium conductance and allosteric coupling of ligand binding to channel opening.Cryo-EM structures of the α7 nicotinic acetylcholine receptor in three major conformational states of the gating cycle—resting, activated, and desensitized—along with functional studies reveal components involved in calcium conductance and allosteric coupling of ligand binding to channel opening.Colleen M. Noviello, Anant Gharpure, Nuriya Mukhtasimova, Rico Cabuco, Leah Baxter, Dominika Borek, Steven M. Sine, Ryan E. Hibbshttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2900238-5%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 18, 2021

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