FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cellsTargeting FBXO44, which regulates the transcriptional silencing of repetitive elements in the human cancer genome, promotes antiviral signaling and decreases tumorigenesis as well as overcomes resistance to immune checkpoint blockade.Targeting FBXO44, which regulates the transcriptional silencing of repetitive elements in the human cancer genome, promotes antiviral signaling and decreases tumorigenesis as well as overcomes resistance to immune checkpoint blockade.Jia Z. Shen, Zhixin Qiu, Qiulian Wu, Darren Finlay, Guillermina Garcia, Dahui Sun, Juha Rantala, William Barshop, Jennifer L. Hope, Ryan C. Gimple, Olle Sangfelt, Linda M. Bradley, James Wohlschlegel, Jeremy N. Rich, Charles Spruckhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931614-7%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 24, 2020

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