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Extensive cross-species transmission of pathogens and antibiotic resistance genes in mammals neglected by public health surveillanceMicrobiome and virome sequencing of non-traditional farmed and wild mammals reveal an uncharted diversity of potential pathogens and mobile antibiotic resistance genes, providing insights into the risks of zoonotic disease and antibiotic resistance at the human-animal interface.Microbiome and virome sequencing […]

Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infectionAdministration of human monoclonal antibodies against the MPXV A35 protein mitigate the pathogenic effects of MPXV infection in mouse and non-human primate models, with structural analyses explaining the basis of their efficacy.Administration of human monoclonal antibodies against the MPXV A35 protein mitigate the […]

Human monoclonal antibodies targeting A35 protect from death caused by mpoxThree potent mAbs against the conserved MPXV A35 protein block viral spread, protect against lethal infection in mice, and align with protective antibody responses in convalescent humans, establishing A35 as a key target for next-generation orthopoxvirus therapies.Three potent mAbs against the conserved MPXV A35 protein […]

Uncovering phenotypic inheritance from single cells with Microcolony-seqMicrocolony-seq systematically uncovers inherited phenotypic diversity directly from infected human samples, revealing that bacteria can retain long-term genetic and nongenetic memory from the host environment. These findings suggest that bacterial memory is widespread and may inform the development of strategies to target the multiple coexisting subpopulations within infections […]

Mitochondrial activity tunes nociceptor resilience to excitotoxicityExcitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport chain components protects against excitotoxic death, as seen in pain-sensing primary afferent neurons (nociceptors).Excitation enables neuronal function; however, overexcitation and calcium overload can […]

The new rules of the data center playbookFlexential CEO Chris Downie outlined a new playbook for data center operators, amid unprecedented demand, investment and chokepoints RESTON, Virginia—The wake-up call for Flexential CEO Chris Downie started innocently enough: He sent a picture of himself meeting former Ukrainian heavyweight boxing champion Wladimir Klitschko to a friend, in […]

Paraguay awards frequencies for 5G servicesThe Government of Paraguay has adopted several measures to effectively restrict Chinese vendors for the provision of 5G gear In sum – what to know: Claro and Nubicom win spectrum – Both companies secured 200 MHz each in Paraguay’s 3.5 GHz band, with 5G rollouts expected in early 2026. New […]