Thermus thermophilus Argonaute Functions in the Completion of DNA ReplicationArgonaute proteins use short nucleic acids as guides. In eukaryotes, these include siRNAs, miRNAs, and piRNAs, whose functions in fighting viruses, regulating gene expression, and silencing transposons have been studied extensively. The functions of Argonaute proteins in bacteria are less well understood. Jolly et al. report that, in the eubacterium Thermus thermophilus, Argonaute derives its DNA guides from the terminus of replication and participates in decatenating circular chromosomes, ensuring successful cell division.Argonaute proteins use short nucleic acids as guides. In eukaryotes, these include siRNAs, miRNAs, and piRNAs, whose functions in fighting viruses, regulating gene expression, and silencing transposons have been studied extensively. The functions of Argonaute proteins in bacteria are less well understood. Jolly et al. report that, in the eubacterium Thermus thermophilus, Argonaute derives its DNA guides from the terminus of replication and participates in decatenating circular chromosomes, ensuring successful cell division.Samson M. Jolly, Ildar Gainetdinov, Karina Jouravleva, Han Zhang, Lara Strittmatter, Shannon M. Bailey, Gregory M. Hendricks, Avantika Dhabaria, Beatrix Ueberheide, Phillip D. Zamorehttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930944-2%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 26, 2020

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