Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell TherapyCD3ε contains multiple motifs that regulate TCR signaling. A CAR-T design incorporating the CD3ε cytoplasmic domain shows reduced cytokine production and enhanced persistence, suggesting the potential of increasing CD3 diversity as a design strategy for improving CAR-T therapy.CD3ε contains multiple motifs that regulate TCR signaling. A CAR-T design incorporating the CD3ε cytoplasmic domain shows reduced cytokine production and enhanced persistence, suggesting the potential of increasing CD3 diversity as a design strategy for improving CAR-T therapy.Wei Wu, Qiuping Zhou, Takeya Masubuchi, Xiaoshan Shi, Hua Li, Xinyi Xu, Min Huang, Li Meng, Xing He, Hengyu Zhu, Shuaixin Gao, Nan Zhang, Ruirui Jing, Jie Sun, Haopeng Wang, Enfu Hui, Catherine Chiulan Wong, Chenqi Xuhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930883-7%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 30, 2020

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