An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T CellsIntegrated chemical proteomics and phenotypic screening furnishes a global portrait of cysteine reactivity and ligandability in primary human T cells and enables the discovery of electrophilic small molecules that suppress T cell activation and promote the degradation of immunomodulatory proteins.Integrated chemical proteomics and phenotypic screening furnishes a global portrait of cysteine reactivity and ligandability in primary human T cells and enables the discovery of electrophilic small molecules that suppress T cell activation and promote the degradation of immunomodulatory proteins.Ekaterina V. Vinogradova, Xiaoyu Zhang, David Remillard, Daniel C. Lazar, Radu M. Suciu, Yujia Wang, Giulia Bianco, Yu Yamashita, Vincent M. Crowley, Michael A. Schafroth, Minoru Yokoyama, David B. Konrad, Kenneth M. Lum, Gabriel M. Simon, Esther K. Kemper, Michael R. Lazear, Sifei Yin, Megan M. Blewett, Melissa M. Dix, Nhan Nguyen, Maxim N. Shokhirev, Emily N. Chin, Luke L. Lairson, Bruno Melillo, Stuart L. Schreiber, Stefano Forli, John R. Teijaro, Benjamin F. Cravatthttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930823-0%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 30, 2020

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